This article examines the Casa delle Zitelle, a charitable institution for young women at risk of falling into prostitution, in early modern Venice. Founded by a group of deeply religious noblewomen, the Casa reflected the social anxieties of the time that linked social ills to prostitution, as well as a new spirit of social activism inspired by religious conviction on the part of the city's elite. The Casa also created a new type of female community that drew both on familial structures and the traditional female networks that were characteristic of Venetian neighborhoods.